Penambatan Molekul Senyawa Volatil Ekstrak Diklorometana Sambiloto Terhadap Onkoprotein Human Epidermal Growth Factor Receptor

  • Muhammad Faisal Departemen Biomedik, Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Abdurrab
  • Nurlaili Nurlaili Departemen Kimia Sintesis, Program Studi Analis Kesehatan, Akademi Kesehatan Kartini Batam
  • Assoc. Prof. Dr. Potchanapond Graidist Department of Biomedical Sciences and Engineering, Faculty of Medicine, Prince of Songkla University
  • Assist. Prof. Dr. Varomyalin Tipmanee Department of Biomedical Sciences and Engineering, Faculty of Medicine, Prince of Songkla University
Keywords: Bitter leaves; EGFR, Molecular docking; Volatile compounds


EGFR oncoprotein has been commonly studied in combating cell cancer development. However, until this moment the EGFR inhibitors were reported to cause other health issues. Plant extracts are trusted as the potential inhibitor of EGFR expression level without affect our health. We previously observed seventeen volatile compounds in the dichloromethane extract of Andrographis paniculata. Our objective was to analyze the interaction of volatile compounds from the dichloromethane extract of Andrographis paniculata on human EGFR pathway. In silico technique with ligand-receptor molecular docking was used in this study. The structure of volatile compounds was set as the ligands. EGFR, PIK3CA, KRAS-GTP, BRAF V600E, and AKT protein structures were assigned as the receptors. PyRx and Biovia Discovery Studio were used in this docking study. Drug-likeness and lead-likeness properties were appraised by SwissADME and Pre-ADME/Tox web tools. Beta-amyrin and stigmasterol showed the highest binding affinity to EGFR oncoproteins. PIK3CA, AKT, and KRAS-GTP, BRAF V600E was bound to beta-amyrin and stigmasterol, respectively. Those compounds structurally showed drug-likeness and non-mutagenic. Briefly, beta-amyrin and stigmasterol will be potentially used as the inhibitors of selected oncoproteins. In vitro technique and animal model are suggested to be performed to validate the mutagenic mechanisms of beta-amyrin and stigmasterol

Author Biography

Muhammad Faisal, Departemen Biomedik, Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Abdurrab

Departemen Biomedik, Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Abdurrab


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How to Cite
Faisal, M., Nurlaili, N., Graidist, P., & Tipmanee, V. (2022). PENAMBATAN MOLEKUL SENYAWA VOLATIL EKSTRAK DIKLOROMETANA SAMBILOTO TERHADAP JALUR PENSINYAL EPIDERMAL GROWTH FACTOR RECEPTOR: Penambatan Molekul Senyawa Volatil Ekstrak Diklorometana Sambiloto Terhadap Onkoprotein Human Epidermal Growth Factor Receptor. JURNAL BIOSENSE, 5(01), 67-80.