LITERATURE REVIEW: POTENSI Cinnamomum zeylanicum DALAM MENINGKATKAN KUALITAS SPERMA MELALUI REGULASI STRES OKSIDATIF

Azzahra Noor Firanti; Yuni Ahda

doi:10.36526/biosense.v9i2.7716

Authors

Azzahra Noor Firanti universitas negeri padang
Yuni Ahda Universitas Negeri Padang

DOI:

https://doi.org/10.36526/biosense.v9i2.7716

Keywords:

cinnamomum zeylanicum, kualitas sperma, antioksidan, stres oksidatif

Abstract

Infertility is a reproductive health issue that affects many couples of reproductive age, and in males it is frequently associated with decreased sperm quality. One of the major contributing factors to impaired sperm quality is oxidative stress, which results from an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system. This imbalance can damage sperm cell membranes, alter DNA integrity, and disrupt the process of spermatogenesis. This study aimed to review the potential of Cinnamomum zeylanicum in improving sperm quality through the regulation of oxidative stress. A literature review approach was employed by examining scientific publications obtained from Google Scholar and ResearchGate within the last ten years. Relevant studies were analyzed descriptively based on research design, observed sperm parameters, and the reported findings. The review indicates that Cinnamomum zeylanicum contains several bioactive compounds, including flavonoids, polyphenols, and cinnamaldehyde, which exhibit strong antioxidant activity. These compounds may reduce oxidative damage and protect sperm cells, thereby potentially improving sperm parameters such as count, motility, and viability.

References

Ahda, Y., Rahma, M., Nilasari, R., & Lyrawati, D. (2025). Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract. BIO Web of Conferences, 154, 03007.

Al-Khamas, A. J. (2018). Effect of Cinnamomum zeylanicum bark water extract on male diabetic albino rats fertility. Basrah Journal of Veterinary Research, 17(1), 123–135.

Al-Shawabkeh, M., & Al Jamal, A. (2019). Effect of cinnamon administration on fertility of normal and diabetic male rats. Pakistan Journal of Nutrition, 18(5), 491–495.

Barakat, H., & El-Masry, S. (2016). Oils of Nigella sativa L. and Cinnamon zeylanicum inhibit the testicular cytotoxicity and genotoxicity induced by mancozeb in rats. International Journal of Biochemistry Research & Review, 14(1), 1–11.

Heidarzadeh, R., & Tabatabaei Vakili, S. (2025). Protective effect of cinnamon (Cinnamomum zeylanicum) extract on the sperm quality during cool storage of ram semen. Veterinary Medicine and Science, 11(3), e70370.

Ibrahim, S., & Abo-Kora, S. Y. (2017). Evaluation of the protective effect of Cinnamomum zeylanicum on cadmium testicular toxicity and Nrf2 gene expression in albino rats. International Journal of Pharmacology and Toxicology, 5(1), 5–10.

Iqra, K. N., Amelia, A. C. R., Tarigan, S. N. Z. B. R., Akbar, I. Q., Ahda, Y., & Atifah, Y. (2023). Pengaruh pemberian ekstrak jahe merah (Zingiber officinale var. rubrum) dalam meningkatkan motilitas dan morfologi spermatozoa mencit (Mus musculus L.). Jurnal Ilmu Kedokteran dan Kesehatan, 10(12), 3417–3425.

Jalil Faddladdeen, K. A. (2022). The possible protective and therapeutic effects of ginger and cinnamon on the testis and coda epididymis of streptozotocin-induced diabetic rats: Histological and biochemical studies. Saudi Journal of Biological Sciences, 29(12), 103452.

Khaki, A. (2015). Effect of Cinnamomum zeylanicum on spermatogenesis. Iranian Red Crescent Medical Journal, 17(2), e18668.

Kiofi, N. B., & Omorodion, N. T. (2022). Stem bark extract of Cinnamomum zeylanicum (cinnamon) could serve a protective role on opioids induced toxicity on male fertility using Sprague Dawley model of rat. World Journal of Biomedical Research, 9(2), 1–7.

Muhammad, A. (2021). Effect of cinnamon bark oil on Leydig cell count and morphology along with serum testosterone levels in rats after cadmium induced testicular toxicity. Pakistan Journal of Medical and Health Sciences, 15(9), 2958-2960.

Muresan, M. L., & Chise, E. (2024). Chemical composition and activity of the essential oil from 25 Cinnamomum species: A mini-review of the literature. Studia Universitatis “Vasile Goldiș” Arad, Seria Științele Vieții (Life Sciences Series), 34(1), 26–31.

Nurhayati, N., Musfirah, M., & Togubu, D. M. (2025). Hubungan merokok, keterpaparan radiasi, kualitas tidur dengan kualitas sperma pada pasien infertil di Klinik Otentik Kota Makassar. Innovative: Journal of Social Science Research, 5(4), 7815–7831.

Rahma, M., & Ahda, Y. (2021). Pengaruh pemberian ekstrak kayu manis (Cinnamomum burmanii) terhadap jumlah spermatozoa pada mencit jantan (Mus musculus L.). Serambi Biologi, 6(1).

Rahmadiani, D. (2021). Ekstrak pollen kurma (Phoenix dactylifera L.) sebagai terapi infertilitas pada pria. Jurnal Ilmiah Kesehatan Sandi Husada, 10(1), 31–40.

Rizal, D. M. (2024). Potensi platelet-rich plasma untuk mengatasi masalah akibat stres oksidatif pada sistem reproduksi pria. UGM Press.

Sariözkan, S., Türk, G., Güvenç, M., Yüce, A., Özdamar, S., Cantürk, F., & Yay, A. H. (2016). Effects of cinnamon (C. zeylanicum) bark oil against taxanes-induced damages in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. Nutrition and Cancer, 68(3), 481–494.

Türk, G., Şimşek, Ü. G., Çeribaşı, A. O., Çeribaşı, S., Kaya, Ş. Ö., Güvenç, M., & Tonbak, F. (2015). Effect of cinnamon (Cinnamomum zeylanicum) bark oil on heat stress-induced changes in sperm production, testicular lipid peroxidation, testicular apoptosis, and androgen receptor density in developing Japanese quails. Theriogenology, 84(3), 365–376.

Ukratalo, A. M., Wedilen, T. F., Tofure, I. R., Manery, D. E., & Ramadhany, M. R. (2022). Improved quality of spermatozoa mice (Mus musculus) model of diabetes mellitus type 1 after being given cinnamon bark methanol extract (Cinnamomum burmanii Bl.). NSMRJ: Nusantara Scientific Medical Research Journal, 1(1), 69–79.

Weerasekera, A. C., Samarasinghe, K., de Zoysa, H. K. S., Bamunuarachchige, T. C., & Waisundara, V. Y. (2021). Cinnamomum zeylanicum: Morphology, antioxidant properties and bioactive compounds. In Antioxidants: Benefits, sources, and mechanisms of action. IntechOpen.